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KMID : 0369820130430060471
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Jorunal of Korean Pharmaceutical Sciences
2013 Volume.43 No. 6 p.471 ~ p.480
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Enhanced solubility and dissolution of simvastatin by HPMC-based solid dispersions prepared by hot melt extrusion and spray-drying method
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Javeer Sharadchandra Dagadu
Patole Rahul
Amin Purnima
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Abstract
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The objective of this study was to use low viscosity grade hydroxypropyl methyl cellulose (Methocel® E3 LV and Methocel® E5 LV) to enhance the solubility and dissolution of poorly water soluble drug simvastatin (SIM). Two different technologies, hot melt extrusion and spray drying were employed. Characterization of hot melt extrudes and spray dried samples was done by Fourier-transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction studies and scanning electron microscopy. The result of the study showed the conversion of crystalline form drug into amorphous form indicating increase in dissolution rate and solubility of SIM.
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KEYWORD
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Simvastatin, Hot melt extrusion, Spray drying, Hydroxypropyl methyl cellulose (HPMC)
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